Low-dose bexarotene and low-dose interferon alfa-2b for adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus 1.
نویسندگان
چکیده
Stephen Richardson, MD; Jeanne B. Budgin, DVM; Jacqueline M. Junkins-Hopkins, MD; Carmela C. Vittorio, MD; Jason Lee, MD; Wallace T. Miller, Jr, MD; Alain H. Rook, MD; Ellen J. Kim, MD; Departments of Dermatology (Drs Richardson, Junkins-Hopkins, Vittorio, Rook, and Kim) and Radiology (Dr Miller), University of Pennsylvania Health System; Department of Dermatology, University of Pennsylvania School of Veterinary Medicine (Dr Budgin); Department of Dermatology, Thomas Jefferson Medical College (Dr Lee), Philadelphia
منابع مشابه
آلودگی با ویروس HTLV1 در جهان و خراسان
Since thee beginning of the present century retroviruses have been reported as causative factors that produced transmissible tumors in birds. However, in 1980 Poiesz et al, established, for the first time, a link between a retrovirus and leukemia called Human Lymphotropic Virus Type 1 (HTLV1). Over the course of past 27 years the epidemiology of human T lymphotropic Virus type l has matured. ...
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PURPOSE Adult T-cell leukemia/lymphoma (ATLL) is a mature (post-thymic) T-cell lymphoma associated with human T-lymphotropic virus type 1 infection. Survival in aggressive subtypes remains poor, and treatment resistance is frequent. Use of zidovudine (ZDV) and interferon alfa (IFN-α) has been associated with improved response rates in small studies and prolonged overall survival in leukemic ATL...
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Background: The human T-cell lymphotropic virus type I is the first retrovirus idenfied in humans. The virus has been associated with adult T-cell leukemia/lymphoma, human T-lymphotropic virus type I, myelopathy/tropical spasc paraparesis, uveis, arthris, pulmonary lymphocyc alveolis, keratoconjuncvis sicca, and infecous dermas. Human T-lymphotropic virus type Iis endemic in Japan...
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Human T-cell lymphotropic virus type I (HTLV-I)–associated adult T-cell leukemia/ lymphoma (ATL) is a malignancy of mature activated T cells resistant to conventional chemotherapy. The viral transactivator protein Tax plays a critical role in HTLV-I– induced transformation and apoptosis resistance by inducing IkB-a degradation, resulting in the activation of the NF-kBpathway. In these HTLV-I–tr...
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ورودعنوان ژورنال:
- Archives of dermatology
دوره 141 3 شماره
صفحات -
تاریخ انتشار 2005